2024 Author: Brian Parson | [email protected]. Last modified: 2023-12-17 15:02
There are two ways to launch new drugs. One is to develop fundamentally new drugs, to invest hundreds of thousands of dollars in their development from scratch, and then if they can successfully pass all the clinical tests and trials of volunteers, these drugs reach us.
The other way is to detect hitherto unsuspected properties of an already existing drug. Very often pharmaceutical companies stop at this option because it is significantly cheaper.
According to a study published in the medical journal Natural Medicine, a forgotten drug used to treat asthma and cold sores can significantly reduce the risk of developing diabetes in overweight people.
Clinical trials in mice have shown that rodents taking amlexanox, better known as Aftazole, lost a significant portion of their overweight, regulated blood insulin production and even improved their liver function.
The advantage of using this medicine is its relative safety. We have very accurate data on its side effects due to its long-term use. This gives us the rare opportunity to shift drug use from treating one disease to treating another,”said Dr. Alan Saltiel, professor and director at the University of Michigan's Institute for Life Studies.
The drug, distributed in the United States and Japan, blocks the action of two genes that are linked to inflammatory processes in the liver in obesity.
The researchers believe that the drug causes a change in the cells by causing them to burn them instead of keeping the excess calories, as shown by the increased body temperature of laboratory mice. In this way, they naturally normalize and regulate insulin levels in their body.
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